pentobarbital will minimize the level or influence of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Pitolisant exposure is decreased by fifty% if coadministered with solid CYP3A4 inducers.pentobarbital will reduce the extent or effect of ixabepilone by impacting hepatic/intestinal enz